Obesity and Diabetes

Low insulin receptor numbers found in adipose tissue of obese rats

Published in Obesity and Diabetes Week, May 3rd, 2004

A low number of insulin receptors, but a high receptor protein content, exist in adipose tissue of rats with monosodium glutamate-induced obesity.

"In order to better understand the mechanisms leading to insulin resistance, the number of fat tissue insulin receptors, their affinity and insulin receptor protein in rats with monosodium glutamate-induced obesity were studied. Obese rats displayed significantly lower number of insulin receptors with high affinity. Surprisingly, the amount of insulin receptor protein was significantly elevated in these animals," scientists in Slovakia report.

"The same relations have been already reported for angiotensin...

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Source: Obesity and Diabetes Week (2004-05-03)

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