Diabetes Pathogenesis
PPAR-alpha deficiency does not alter insulin sensitivity in mice
Published in Obesity and Diabetes Week, May 17th, 2004
"Chronic peroxisome proliferator-activated receptor (PPAR)-alpha activation improves glucose metabolism in rodent models of insulin resistance and diabetes; however, PPAR-alpha deficiency was also reported to protect against high-fat diet (HFD)-induced insulin resistance. The aim of this study was to clarify the role of PPAR-alpha in the development of insulin resistance using PPAR-alpha knockout (KO) mice and wild-type controls (WT).
"Both WT and PPAR-alpha KO mice on HFD gained significantly more weight...
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