Myeloma

IL-6 and IGF-1 highly express IL-6 receptor alpha in myeloma cells

Published in Obesity and Diabetes Week, May 17th, 2004

Receptor synergy occurs with interleukin-6 (IL-6) and insulin-like growth factor-1 that highly express IL-6 receptor alpha in myeloma cells.

"Interleukin-6 (IL-6) is a growth and anti-apoptotic factor for human myeloma cells. The autocrine loop and increased expression of the growth factor receptors have been postulated as the mechanisms of tumorigenesis. Here we show that IL-6 stimulation induced the phosphorylation of insulin-like growth factor-1 (IGF-1) receptors in a human myeloma cell line, NOP2, highly expressing IL-6 receptor alpha (IL-6Ralpha) and in the IL-6Ralpha-transfected U266 cell line," scientists in Japan report.

"IL-6-dependent...

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Source: Obesity and Diabetes Week (2004-05-17)

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