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Diabetes Genomics and Genetics
Method to detect DNA mutation applied to family with diabetes
May 31st, 2004
Scientists have applied a gel electrophoresis method for detection of mitochondrial DNA mutation to a Norwegian family with diabetes and hearing loss. According to a study from Norway, "Blood cells of selected patients from a large Norwegian family with maternally transmitted diabetes mellitus, hearing loss, and muscular dysfunction were screened for possible A3243G mutation tRNA(LeuUUR ) in mitochondrial DNA. We selected seven patients from three of the four generations of the family and 10 unrelated healthy control subjects for mutation analysis using denaturing gradient gel electrophoresis (DGGE) and both manual and automated DNA sequencing. ...
Source: Obesity & Diabetes Week (2004-05-31)
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