Obesity & Diabetes Week
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Diabetes Pathogenesis
Cytokine gene expression in diabetes pathogenesis discussed
May 31st, 2004
The role of cytokine gene expression in the peritoneal macrophages and splenic CD4- and CD8-positive lymphocytes of nonobese diabetic mice is discussed in a recent issue of the Journal of Clinical Immunology. "Type 1 diabetes is an autoimmune disease that results from the destruction of the insulin-producing pancreatic beta islet cells, probably via the influence of cytokines. However, direct correlation between the expression of selected cytokines by various immune cells at different time points during the progression of the disease has not yet been clearly demonstrated. In this study, we showed that the mRNA expression of the pro-inflammatory cytokines,...
Source: Obesity & Diabetes Week (2004-05-31)
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