Obesity & Diabetes Week
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Diabetes Pathogenesis
Mammalian target of rapamycin regulates IRS-1 serine phosphorylation
May 31st, 2004
A mammalian target of rapamycin regulates insulin receptor substrate (IRS)-1 serine 307 phosphorylation. According to published research from the United States, "Insulin signaling can be negatively regulated by phosphorylation of serine 307 of the insulin receptor substrate (IRS)-1. Rapamycin, an inhibitor of the kinase mTOR, can prevent serine 307 phosphorylation and the development of insulin resistance. We further investigated the role of mTOR in regulating serine 307 phosphorylation, demonstrating that serine 307 phosphorylation in response to insulin, anisomycin, or tumor necrosis factor was quantitatively and temporally associated with activation of mTOR and could...
Source: Obesity & Diabetes Week (2004-05-31)
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