Obesity & Diabetes Week
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Diabetes Pathogenesis
c-Maf and MafA activate insulin gene expression in beta-cells
May 31st, 2004
Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells. According to published research from Japan, "A basic-leucine zipper transcription factor, MafA, was recently identified as one of the most important transactivators of insulin gene expression. This protein controls the glucose-regulated and pancreatic beta-cell-specific expression of the insulin gene through a cis-regulatory element called RIPE3b/MARE (Maf-recognition element). Here, we show that MafA expression is restricted to beta-cells of pancreatic islets in vivo and in insulinoma cell lines. ...
Source: Obesity & Diabetes Week (2004-05-31)
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