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Diabetes Therapy
Palmitate-derivatized GLP-1 analogues exhibit antihyperglycemic action
May 31st, 2004
Palmitate-derivatized GLP-1 analogues exhibit antihyperglycemic activities. "The hormone glucagon-like peptide-1(736)amide (GLP-1) is released in response to ingested nutrients and acts to promote glucose-dependent insulin secretion ensuring efficient postprandial glucose homeostasis. Unfortunately, the beneficial actions of GLP-1 which give this hormone many of the desirable properties of an antidiabetic drug are short lived due to degradation by dipeptidylpeptidase IV (DPP IV) and rapid clearance by renal filtration," scientists in Ireland report. "In this study we have attempted to extend GLP-1 action through the attachment of palmitoyl moieties...
Source: Obesity & Diabetes Week (2004-05-31)
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