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Endocrinology
Cholecystokinin-mediated suppression of feeding involves melanocortin
May 31st, 2004
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. "Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety," investigators in the United States report. "We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term...
Source: Obesity & Diabetes Week (2004-05-31)
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