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Endocrinology
Method to determine incretin hormone levels in human plasma developed
May 31st, 2004
Researchers have developed a method for the simultaneous determination of incretin hormones and their truncated forms from human plasma by immunoprecipitation and liquid chromatography-mass spectrometry. "The incretins, glucose-dependent insulinotropic peptide (GPI1-42 ) and glucagon-like peptide I (GLP-17-36 ), are involved in regulation of gastric emptying, glucose homeostasis, body fat regulation and the glucose-induced insulin secretion from the endocrine pancreas. After release in the circulation both peptides are rapidly degraded by the exopeptidase dipeptidyl peptidase IV (DP IV) to the inactive polypeptides GIP3-42 and...
Source: Obesity & Diabetes Week (2004-05-31)
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