Obesity & Diabetes Week
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Endocrinology
Phosphorylation site in elongation factor 2 kinase modulates activity
May 31st, 2004
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. According to a study from Scotland, "Eukaryotic elongation factor 2 (eEF2) kinase is an unusual calcium- and calmodulin-dependent protein kinase that is regulated by insulin through the rapamycin-sensitive mTOR pathway. Here we show that insulin decreases the ability of eEF2 kinase to bind calmodulin in a rapamycin-sensitive manner. We identify a novel phosphorylation site in eEF2 kinase (Ser78) that is located immediately next to its calmodulin-binding motif. "Phosphorylation of this site is increased by...
Source: Obesity & Diabetes Week (2004-05-31)
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