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Heart Disease Risk Factor
Gender-dependent attenuation of cardiac K currents reported in diabetes
May 31st, 2004
Gender-dependent attenuation of cardiac potassium currents has been reported in type 2 diabetic db/db mice. "Single ventricular myocytes were prepared from control db/+ and insulin-resistant diabetic db/db male mice at 6 and 12 weeks of age. Peak and sustained outward potassium currents were measured using whole-cell voltage clamp methods. At 6 weeks currents were fully developed in control and diabetic mice, with no differences in the density of either current," investigators in Canada report. "By 12 weeks both currents were significantly attenuated in the diabetic mice, but could be augmented by in vitro incubation with the angiotensin-converting...
Source: Obesity & Diabetes Week (2004-05-31)
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