Obesity & Diabetes Week
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Insulin Delivery
P(MAA-g-EG) hydrogels used for oral insulin delivery
May 31st, 2004
Scientists investigated the effects of network morphology on insulin delivery characteristics of P(MAA-g-EG) hydrogels. "Hydrogels of poly(methacrylic acid-g-ethylene glycol) were prepared using different reaction water contents in order to vary the network mesh size, swelling behavior, and insulin loading/release kinetics. Gels prepared with greater reaction solvent contents swelled to a greater degree and had a larger network mesh size. All of the hydrogels were able to incorporate insulin and protected it from release in acidic media," scientists in the United States report. "At higher pH (7.4), the release rates increased with reaction solvent...
Source: Obesity & Diabetes Week (2004-05-31)
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