Obesity & Diabetes Week
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Insulin Resistance
Muscle insulin receptor knockout mice provide new model diabetes study
May 31st, 2004
Muscle insulin receptor knockout mice provide an interesting new model for the study of insulin resistance and diabetes. According to recent research from France, "White adipose tissue (WAT) plays a critical role in the development of insulin resistance via secretion of free fatty acids (FFA) and adipocytokines. Muscle-specific insulin receptor knockout (MIRKO) mice do not develop insulin resistance or diabetes under physiological conditions despite a marked increase in adiposity and plasma FFA. On the contrary, WAT of MIRKO is sensitized to insulin action during a euglycemic clamp, and WAT glucose utilization is dramatically increased. "To get...
Source: Obesity & Diabetes Week (2004-05-31)
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