Obesity & Diabetes Week
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Leptin Studies
Leptin rapidly rewires arcuate nucleus feeding circuits
May 31st, 2004
Leptin has the ability to rapidly rewire arcuate nucleus feeding circuits. According to recent research from the United States, "The fat-derived hormone leptin regulates energy balance in part by modulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate nucleus. To study the intrinsic activity of these neurons and their responses to leptin, we generated mice that express distinct green fluorescent proteins in these two neuronal types. "Leptin-deficient (ob/ob) mice differed from wild-type mice in the numbers of excitatory and inhibitory synapses and postsynaptic currents onto neuropeptide Y and...
Source: Obesity & Diabetes Week (2004-05-31)
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