Obesity & Diabetes Week
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Appetite
Ghrelin receptor activity is signaling set-point in appetite regulation
May 31st, 2004
Constitutive ghrelin receptor activity is a signaling set-point in appetite regulation. According to a study from Denmark, "Ghrelin plays a key role as the major orexigenic hormone from the gastrointestinal tract to the hypothalamic areas that govern food intake, balancing against a multitude of anorectic hormones, such as leptin, insulin and PYY3-36 . "Surprisingly, even in the absence of agonist, the ghrelin receptor signals with {{appprox}}50% activity," said Birgitte Holst and Thue W. Schwartz at the University of Copenhagen. "Thus, although ghrelin receptor antagonists are expected to reduce meal-associated food intake, inverse...
Source: Obesity & Diabetes Week (2004-05-31)
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