HIV/AIDS Research
HIV-1 APIs modulate Ca2+ signaling in secretory epithelial cells
Published in Obesity and Diabetes Week, June 7th, 2004
"Aspartyl protease inhibitors (APIs) effectively extend the length and quality of life in human immunodeficiency virus (HIV)-infected patients, but dose-limiting side effects such as lipodystrophy, insulin resistance, and diarrhea have limited their clinical utility," wrote investigators at Harvard University. "Here, we show that the API nelfinavir induces a secretory form of diarrhea in HIV-infected patients."
"In vitro studies demonstrate that nelfinavir potentiates muscarinic stimulation of Cl- secretion by T84 human intestinal cell monolayers...
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