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Obesity Genomics and Genetics

5-HT2C receptor promoter polymorphism associated with obesity in women

Published in Obesity and Diabetes Week, June 7th, 2004

A 5-HT2C receptor promoter polymorphism (HTR2C-759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes.

"The serotonin 5-HT2C receptor (HTR2C) helps regulate appetite and body weight. An HTR2C promoter polymorphism (-759C/T) has been associated with obesity and with weight gain in response to antipsychotic (neuroleptic) drugs. We studied this polymorphism in 120 obese women (BMI{{>=}}30) and 104 non-obese (BMI{{<=}}25) women. The C allele was commoner in the obese group (OR=1.72 [95% CI, 1.13-2.64], p=0.008)," scientists in England report.

"Ninety-five of the obese women participated in a randomized...

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