Ophthalmology
Angiopoietin-2 influences the pathogenesis of diabetic retinopathy
Published in Obesity and Diabetes Week, June 7th, 2004
According to recent research published in the journal Diabetes, "pericyte loss is an early pathologic feature of diabetic retinopathy, consistently present in retinae of diabetic humans and animals."
"Because pericyte recruitment and endothelial cell survival are controlled, in part, by the angiopoietin/Tie2 ligand/receptor system, we studied the expression of angiopoietin (Ang)-2 and -1 in relation to the evolution of pericyte loss in diabetic rat retinae, using quantitative retinal morphometry, and in retinae from mice with heterozygous angiopoietin deficiency (Ang-2 LacZ...
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