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Diabetes Therapy

Interaction of serum albumin with novel antidiabetic agent described

Published in Obesity and Diabetes Week, June 14th, 2004

Scientists describe the interaction of human serum albumin with a novel antidiabetic agent in a recent issue of the Journal of Pharmaceutical Sciences.

According to published research from China, "SU-118 is a newly synthesized antidiabetic agent and shows the best hypoglycemic effect among a series of analogs. Its binding properties and binding sites located on human serum albumin (HSA) have been studied using UV absorption and fluorescence spectroscopy. The results of spectroscopic study and the thermodynamic parameters obtained suggest that SU-118 binds to the hydrophobic cavity of human serum albumin and the hydrophobic interaction is the predominant...

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