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Lipid Studies

Lipoprotein profiles under varied androgen blockade conditions reported

Published in Obesity and Diabetes Week, June 21st, 2004

Scientists have determined the plasma lipoprotein profile in the male cynomolgus monkey under normal, hypogonadal, and combined androgen blockade conditions.

According to a study from Canada, "In men, orchiectomy (GDX) produces an atherogenic lipid profile, whereas combined androgen blockade (CAB) induces a favorable lipid pattern.

"To better understand the opposite effects of GDX and CAB on lipid metabolism, we have compared the changes in plasma lipoproteins, mesenteric fat metabolism, as well as serum and intratissular sex steroid concentrations in intact, GDX, and GDX + FLU [GDX male cynomolgus monkeys treated for three months with flutamide...

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