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Lipid Studies

New class of lipid absorption inhibitor from sage discovered

Published in Obesity and Diabetes Week, June 21st, 2004

Carnosic acid represents a new class of lipid absorption inhibitor from sage.

According to a study from Japan, "The methanolic extract from the leaves of Salvia officinalis (sage) showed significant inhibitory effect on serum triglyceride elevation in olive oil-loaded mice (500 and 1,000 mg/kg, p.o.) and inhibitory activity (IC50 : 94 mcg/mL) against pancreatic lipase, which is participated in digestion of lipids."

"Through bioassay-guided separation using the inhibitory activity against pancreatic lipase activity, 4 abietan-type diterpenes (carnosic acid, carnosol, royleanonic acid, 7-methoxyrosmanol), and a triterpene (oleanolic...

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