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Pulmonary Medicine

Diminished lung compliance found in nutritionally obese young rats

Published in Obesity and Diabetes Week, July 5th, 2004

Lung compliance is diminished and surfactant lipids and proteins are elevated in nutritionally obese young rats.

According to recent research published in the journal Lung, "Dietary-induced obesity is associated with increases in lung weight, lung volume, alveolar surface area, and number of lamellar bodies in alveolar epithelial type II cells. This suggests that alterations in lung compliance and surfactant content may also occur. The effects of dietary-induced obesity on lung function and surfactant composition were studied in newborn male rats raised in small litters until weaning and then fed a high-fat diet (obese group, n=23) and normal-sized litters until...

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