Diabetes Vaccine

BAX with DNA vaccine promotes efficacy of diabetes prevention in mice

Published in Obesity and Diabetes Week, July 12th, 2004

Co-delivery of pro-apoptotic BAX with a DNA vaccine recruits dendritic cells and promotes efficacy of autoimmune diabetes prevention in mice.

According to published research from the United States, "Genetic vaccines encoding pancreatic beta cell antigens can prevent autoimmune (type 1) diabetes when delivered into murine model systems, but there is a need to improve their efficacy. Here, we investigated the effects of intramuscular delivery of DNA coding for the pro-apoptotic protein BAX together with an intracellular or a secreted form of the beta cell antigen glutamic acid decarboxylase (GAD) on diabetes onset and immune responses in non-obese diabetic (NOD) mice. We...

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Source: Obesity and Diabetes Week (2004-07-12)

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