Obesity Genomics and Genetics

Abnormal vascular innervation found in hypothalamus of obese mice

Published in Obesity and Diabetes Week, July 12th, 2004

Scientists have found abnormal cholinergic and GABAergic vascular innervation in the hypothalamic arcuate nucleus of obese tub/tub mice.

According to recent research published in the journal Synapse, "Tubby and tubby-like proteins (TULPs) are encoded by members of a small gene family. An autosomal recessive mutation in the mouse tub gene leads to blindness, deafness, and maturity-onset obesity. The mechanisms by which the mutation causes the obesity syndrome has not been established. We compared obese tub/tub mice and their lean littermates in order to find abnormalities within the mediobasal hypothalamus, a region intimately associated with the regulation of...

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Source: Obesity and Diabetes Week (2004-07-12)

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