Diabetes Pathogenesis

Neomycin prevents glucose transport in 3T3-L1 adipocytes

Published in Obesity and Diabetes Week, July 19th, 2004

Neomycin prevents the wortmannin inhibition of insulin-stimulated glut4 translocation and glucose transport in 3T3-L1 adipocytes.

"Insulin stimulates the movement of the facilitative glucose transporter glucose transporter-4 (Glut4) from an intracellular compartment to the plasma membrane in adipocytes and muscle cells, resulting in an increased rate of glucose uptake. Insulin-stimulated Glut4 translocation and glucose transport are abolished by wortmannin, a specific inhibitor of phosphatidylinositol 3'-kinase (PI3K)," scientists in Scotland report.

"Here, we demonstrate that neomycin, a drug that masks the cellular substrate of PI3K,...

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Source: Obesity and Diabetes Week (2004-07-19)

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