Adipogenesis
RNA knockdown of phospholipase inhibits preadipocyte differentiation
Published in Obesity and Diabetes Week, July 19th, 2004
"Alterations in lipid secondary messenger generation and lipid metabolic flux are essential in promoting the differentiation of adipocytes. To determine whether specific subtypes of intracellular phospholipases A2 (PLA2 s) facilitate hormone-induced differentiation of 3T3- L1 cells into adipocytes, we examined alterations in the mRNA level, protein mass, and activity of three previously characterized mammalian intracellular PLA2 s," scientists writing in the Journal of Biological...
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