Obesity Therapy
Oxyntomodulin reduces food intake and body weight gain in rats
Published in Obesity and Diabetes Week, August 2nd, 2004
According to a study from England, "Oxyntomodulin (OXM) is a circulating gut hormone released post prandially from cells of the gastrointestinal mucosa. Given intracerebroventricularly to rats, it inhibits food intake and promotes weight loss. Here we report that peripheral (ip) administration of OXM dose-dependently inhibited both fast-induced and dark-phase food intake without delaying gastric emptying. Peripheral OXM administration also inhibited fasting plasma ghrelin."
"In addition, there was a significant increase in c-fos immunoreactivity, a marker of neuronal 14...
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