Diabetes Therapy
Pancreatic duct cells exert tissue factor-dependent procoagulant activity
Published in Obesity and Diabetes Week, August 9th, 2004
"Activation of the coagulation cascade contributes to early graft loss and intraportal thrombotic events in clinical islet transplantation. Although these complications were shown to be related to the presence of tissue factor in human islet preparations, the contribution of duct cells, which represent a major contaminant of clinical islet isolates, has not been specified so far," scientists in Belgium report.
"Herein, we used flow cytometry, immunohistochemistry, RT-PCR, and functional coagulation assays to demonstrate that duct cells exert a potent factor VII-dependent...
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