Leptin Studies

Leptin receptor gene polymorphisms affect glucose homeostasis

Published in Obesity and Diabetes Week, August 9th, 2004

Leptin and leptin receptor gene polymorphisms affect glucose homeostasis in response to regular exercise in nondiabetic individuals.

According to a study from the United States, Finland, and Canada, "We recently reported that a genomic region close to the leptin locus was linked to fasting insulin response to exercise training in nondiabetic white subjects. We tested the hypothesis that common exonic variants in the leptin (LEP) and leptin receptor (LEPR) genes modify the effects of regular physical activity on glucose homeostasis in nondiabetic Whites (n=397) and Blacks (n=143)."

"In Whites, exercise increased insulin sensitivity index (p=0.041) and...

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Source: Obesity and Diabetes Week (2004-08-09)

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