Obesity and Diabetes
Catabolic action of insulin not enhanced by exogenous 'tub' expression
Published in Obesity and Diabetes Week, August 9th, 2004
"The central nervous system (CNS) protein 'tub' has been identified from the genetically obese 'tubby' mouse. Although the native function of tub in situ is not understood, cell-based studies suggest that one of its roles may be as an intracellular signaling target for insulin. In normal animals, insulin acts at the hypothalamic arcuate nucleus (ARC) to regulate energy balance," scientists in the United States report.
"Here we used a herpes simplex viral expression system to evaluate whether tub overexpression in the ARC of normal rats enhances this...
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