Obesity and Diabetes

New paradigm for diabetes and obesity proposed

Published in Obesity and Diabetes Week, August 16th, 2004

Scientists propose a new paradigm for diabetes and obesity called the hepatic insulin sensitizing substance (HISS) hypothesis.

According to published research from Canada, "The glucose disposal effect of insulin after a meal is accounted for in approximately equal measure by the direct action of insulin and the action of HISS (hepatic insulin sensitizing substance) released from the liver and acting on skeletal muscle to stimulate glucose storage as glycogen. The ability of insulin to cause HISS release is determined by hepatic parasympathetic nerves. Eliminating the parasympathetic signal by surgical denervation of the liver or by blockade of hepatic muscarinic...

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Source: Obesity and Diabetes Week (2004-08-16)

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