Obesity Genomics & Genetics

Link found between 3A/4A polymorphism and endothelin-1 levels

Published in Obesity and Diabetes Week, August 16th, 2004

An association exists between the 3A/4A polymorphism and endothelin-1 levels.

According to recent research from Japan, "Endothelin-1 (ET-1) is a potent vasoconstrictor and shows various pharmacological responses. Two single nucleotide polymorphisms in the ET-1 gene (EDN1) have been reported to be associated with blood pressure (BP). One is the Lys198Asn polymorphism, which showed a positive association with BP in overweight people. Another is the 3A/4A polymorphism (-134delA) located in the 5'-untranslated region. In this study, we investigated the expression of the Lys198Asn polymorphism in ET-1 in vitro, as well as the association between either of the two...

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Source: Obesity and Diabetes Week (2004-08-16)

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