Diabetes Therapy
Exposure to tolbutamide and glibenclamide impairs insulin secretion
Published in Obesity and Diabetes Week, August 23rd, 2004
According to published research from Ireland, "Clonal insulin-secreting BRIN-BD11 cells were used to examine effects of chronic 72- to 144-hour exposure to the sulphonylureas tolbutamide and glibenclamide on insulin release, cellular insulin content, and mRNA levels of the Kir6.2 and SUR1 subunits of the beta-cell K-ATP channel.
Chronic exposure for 72-144 hours to 5-100 micromolar tolbutamide and glibenclamide resulted in a time- and concentration-dependent irreversible decline in sulphonylurea-induced insulin...
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