Diabetes Therapy
PPAR activation induces tissue-specific effects on metabolism in vivo
Published in Obesity and Diabetes Week, August 30th, 2004
According to a study from Australia and Sweden, "Agonists of peroxisome proliferator-activated receptors (PPARs) have emerged as important pharmacological agents for improving insulin action. A major mechanism of action of PPAR agonists is thought to involve the alteration of the tissue distribution of nonesterified fatty acid ( NEFA) uptake and utilization. To test this hypothesis directly, we examined the effect of the novel PPAR-alpha/-gamma agonist tesaglitazar on whole-body insulin sensitivity and NEFA clearance into epididymal...
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