Obesity Pathogenesis
Expression of agouti-related protein mRNA down-regulated in obese mice
Published in Obesity and Diabetes Week, September 6th, 2004
According to recent research published in the journal Molecular Brain Research, "A mutation in the mouse tub gene causes a phenotype characterized by maturity-onset obesity, blindness and deafness. The role of the intact tubby protein and the pathogenesis resulting in the phenotype of tub/tub mice remain largely unknown. In this study, we have investigated whether obese tub/tub mice exhibit altered expression levels for agouti-related protein (AGRP) or glutamic acid decarboxylase-65 (GAD65) in body weight-regulating neurons...
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