Diabetes Genomics and Genetics
-866A/A genotype in uncoupling protein gene raises type 2 diabetes risk
Published in Obesity and Diabetes Week, September 13th, 2004
"Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane carriers that uncouple proton entry in the mitochondrial matrix from ATP synthesis. The -866G/A polymorphism in the UCP2 gene, which enhances its transcriptional activity, was associated with enhanced risk for type 2 diabetes in obese subjects. We addressed the question of whether the -866G/A polymorphism contributes to variation in insulin sensitivity by genotyping 181 nondiabetic offspring of type 2 diabetic patients," scientists writing in...
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