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Insulin Resistance

Physiopathology of insulin resistance reviewed

Published in Obesity and Diabetes Week, September 13th, 2004

Researchers review the physiopathology of insulin resistance in a recent issue of the journal Presse Medicale.

According to a study from France, "Among the biological mediators of insulin resistance, two compounds released by the adipocyte are found, such as free fatty acids and tumor necrosis factor-alpha. They are incriminated in the deleterious role of visceral adiposity on metabolic parameters. Intra-cell cortisol also is implicated in the genesis of the metabolic syndrome, because cortisol is a potent antagonist of insulin and its presence in excess enhances visceral obesity and insulin resistance."

"Although no major locus has yet been...

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