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Obesity and Diabetes
Family of Acrp30/adiponectin structural and functional paralogs reviewed
September 27th, 2004
Scientists review a family of Acrp30/adiponectin structural and functional paralogs in a recent issue of the Proceedings of the National Academy of Sciences of the United States of America. "Biochemical, genetic, and animal studies in recent years have established a critical role for the adipokine Acrp30/adiponectin in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. We describe a widely expressed and highly conserved family of adiponectin paralogs designated as C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. In the present study, we focus on...
Source: Obesity & Diabetes Week (2004-09-27)
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