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Exercise
AMPK activity diminished in tissues of IL-6 knockout mice
September 27th, 2004
AMPK activity is diminished in tissues of IL-6 knockout mice. According to published research from the United States and Denmark, "Following exercise, AMP-activated protein kinase (AMPK) activity is increased several fold in rat liver and adipose tissue as well as muscle; however, the mechanism by which this occurs is not known. Interleukin-6 (IL-6) is released from muscle in large amounts during and after sustained physical activity resulting in up to 100-fold increases in its plasma concentration, from 1-2 ng/mL to 50-100 ng/mL. We report here that incubation with IL-6 (30-120 ng/mL) increases the phosphorylation of AMPK (an indicator of its activation) and that of...
Source: Obesity & Diabetes Week (2004-09-27)
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