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Body Mass Index

BMI determines evoked growth hormone responsiveness in healthy male subjects

"GH secretion is decreased in obese subjects, whereas age-adjusted IGF-I concentrations are normal. This study was undertaken to rigorously delineate the extent of obesity [elevated body mass index (BMI)] associated with decreased somatotrope secretory function resulting in apparent adult GH deficiency. The peak GH response evoked by combined arginine (0.5 g/kg infused i.v. over 30 min) and GHRH (1 mcg/kg i.v. bolus) was measured in 59 healthy male subjects with BMIs ranging from normal to obese," scientists writing in the Journal of Clinical Endocrinology and...