Diabetes Therapy
Sulfonylurea and phosphodiesterase inhibitors increase insulin secretion
Published in Obesity and Diabetes Week, October 4th, 2004
"The effects on insulin secretion from INS-1 cells of varying concentrations of the sulfonylurea glyburide and the PDE3 inhibitor milrinone, separately and in combination were measured. Over a range of concentrations the effects of the two drugs in combination were more than additive. A response surface model was fit to the data and was found to describe the data well," scientists writing in the journal Life Sciences report.
"From this model, it was apparent that a significant synergistic effect upon insulin...
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