Published in Obesity and Diabetes Week, October 18th, 2004
"Insulin resistance in obesity is partly due to diminished glucose transport in myocytes and adipocytes, but underlying mechanisms are uncertain. Insulin-stimulated glucose transport requires activation of phosphatidylinositol (PI) 3-kinase (3K), operating downstream of insulin receptor substrate-1. PI3K stimulates glucose transport through increases in PI3,4,5-(PO4 )3 (PIP3 ), which activates atypical protein kinase C (aPKC) and protein...
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