Obesity and Diabetes

Adipocytes of obese subjects exhibit impaired activation of protein kinase C

Published in Obesity and Diabetes Week, October 18th, 2004

Cultured preadipocyte-derived adipocytes and myotubes of obese subjects exhibit impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO₄ )₃ .

"Insulin resistance in obesity is partly due to diminished glucose transport in myocytes and adipocytes, but underlying mechanisms are uncertain. Insulin-stimulated glucose transport requires activation of phosphatidylinositol (PI) 3-kinase (3K), operating downstream of insulin receptor substrate-1. PI3K stimulates glucose transport through increases in PI3,4,5-(PO₄ )₃ (PIP₃ ), which activates atypical protein kinase C (aPKC) and protein...

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Source: Obesity and Diabetes Week (2004-10-18)

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