Published in Obesity and Diabetes Week, October 25th, 2004
According to a study from Sweden, "Pancreatic beta cells respond to glucose stimulation with increase of the cytoplasmic Ca2+ concentration ([Ca2+]i ), manifested as membrane-derived slow oscillations sometimes superimposed with transients of intracellular origin. The effect of external ATP on the oscillatory Ca2+ signal for pulsatile insulin release was studied by digital imaging of fura-2 loaded beta cells and small aggregates isolated from islets of ob/ob-mice. Addition of ATP (0.01-100 micromolar)...
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