Diabetes Pathogenesis

Pulses of external ATP aid synchronization of pancreatic beta cells

Published in Obesity and Diabetes Week, October 25th, 2004

Pulses of external ATP aid the synchronization of pancreatic beta cells by generating premature Ca²⁺ oscillations.

According to a study from Sweden, "Pancreatic beta cells respond to glucose stimulation with increase of the cytoplasmic Ca²⁺ concentration ([Ca²⁺]_i ), manifested as membrane-derived slow oscillations sometimes superimposed with transients of intracellular origin. The effect of external ATP on the oscillatory Ca²⁺ signal for pulsatile insulin release was studied by digital imaging of fura-2 loaded beta cells and small aggregates isolated from islets of ob/ob-mice. Addition of ATP (0.01-100 micromolar)...

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Source: Obesity and Diabetes Week (2004-10-25)

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