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Alcohol Use

Ethanol effects on uncoupling protein-1 mRNA alter thermogenesis set point

Published in Obesity and Diabetes Week, November 1st, 2004

The effects of ethanol on uncoupling protein-1 mRNA in brown adipose tissue alter the thermogenesis set point.

According to recent research from Japan, "Expression of uncoupling protein-1 (UCP1) is increased by cold acclimation and overfeeding, and reduced in fasting and genetic obesity. It is known that the mitochondrial UCP1 in the brown adipose tissue (BAT) is an important key molecule for non-shivering thermogenesis. On the other hand, ethanol (EtOH) alters thermoregulation in humans and laboratory animals. However, the relationship between EtOH intake and UCP1 expression is not yet clear. Accordingly, the present study employed the technique of real-time...

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