Autoimmunity
Retrogenic mice expand opportunities for exploring autoantigens
Published in Obesity and Diabetes Week, November 8th, 2004
"T-cell receptor (TCR) transgenic mice are valuable tools for dissecting the role of autoantigen-specific T cells in the pathogenesis of type 1 diabetes but are time-consuming to generate and backcross onto congenic strains," scientists writing in the Journal of Immunology report.
"To circumvent these limitations, we developed a new approach to rapidly generate mice expressing TCR using retroviral-mediated stem cell gene transfer and a novel picornavirus-like 2A peptide to link the TCR alpha- and beta-chains in a single retroviral vector. We refer to these as retrogenic (Rg) mice...
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