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Diabetic Nephropathy

PAI-1, uPA, and uPAR expression linked to mesangial expansion

Published in Obesity and Diabetes Week, November 8th, 2004

Altered expression of plasminogen-activator inhibitor-1 (PAI-1), urokinase-type plasminogen activator (uPA), and uPA receptor (uPAR) in diabetic nephropathy was associated with mesangial expansion.

According to recent research published in the Journal of Laboratory and Clinical Medicine, "Plasmin is an important factor in the degradation of extracellular matrix. In the study reported here we examined the expression of plasminogen-activator inhibitor-1 (PAI-1), urokinase-type plasminogen activator (uPA), and uPA receptor (uPAR), as well as the relevance of such expression to the production of type IV collagen, a major component of extracellular matrix, in the...

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