Obesity Pathogenesis
Lack of protein kinase-alpha 2 subunit promotes lipid storage
Published in Obesity and Diabetes Week, November 8th, 2004
"AMP-activated protein kinase (AMPK) is considered as a cellular energy sensor that regulates glucose and lipid metabolism by phosphorylating key regulatory enzymes. Despite the major role of adipose tissue in regulating energy partitioning in the organism, the role of AMPK in this tissue has not been addressed. In the present study, we subjected AMPKalpha2 knockout (KO) mice to a high-fat diet to examine the effect of AMPK on adipose tissue formation," researchers in the United States and France report.
"Compared with the wild-type,...
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