Insulin Delivery
Tetradecylmaltoside allows insulin to enter nasal epithelial cells
Published in Obesity and Diabetes Week, November 8th, 2004
"The effect of tetradecylmaltoside (TDM) on nasal peptide drug absorption was assessed with four peptides of distinct molecular size: insulin (5.7 kDa), leptin (16 kDa), somatropin (22.1 kDa), and epoetin alfa (30.4 kDa). The nasal uptake of the smallest peptides, insulin and leptin, was significantly increased at a TDM concentration of only 0.06%. The uptake of somatropin was significantly increased when concentrations of 0.125% or more were used," researchers in the United States report.
"The uptake of the largest peptide, epoetin alfa, was not significantly increased, in the...
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