Obesity Pathogenesis
Mutations in serotonin receptor not linked to early-onset human obesity
Published in Obesity and Diabetes Week, November 8th, 2004
According to recent research published in the Canadian Journal of Physiology and Pharmacology, "Deletion of the serotonin receptor 5-HT2C in mice results in increased food intake and obesity. We screened 95 individuals with severe early-onset obesity for mutations in the coding sequence of this gene. We found a novel missense variant c.1255A>G (Thr419Ala) in a single Caucasian subject that was not found in 192 Caucasian control subjects."
"In transiently-transfected COS cells, the Thr419Ala variant was indistinguishable...
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